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Butea superba (Kwao Krua Dang) Benefits Overview

A species related to Pueraria mirifica, Butea superba is called locally “Kwao Kreu Dang” or Red Kwao Krua. Its name comes from the red sap which comes from the long tuberous root. Red Kwao Krua (Butea superba), is abundantly distributed in the Thai deciduous forest and has been popular among Thai males for the purpose of rejuvenation and increasing sexual vigor.

The tuberous roots of Thai Butea superba were found to contain flavonoid and flavonoid glycoside with cAMP phosphodiesterase inhibitor activity as well as sterol compounds, including b-sitosterol, campesterol and stigmasterol. A Thai traditional medicine with Butea superba as a major ingredient has long been accepted as an effective treatment of ED.

Erectile Dysfunction: Abstract from: Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction.. W. Cherdshewasart, N. Nimsakul

Aim: To study the effect of Butea superba on erectile dysfunction (ED) in Thai males.

Methods: A 3-month randomized double-blind clinical trial was carried out in volunteers with ED, aged 30 years ~ 70 years, to evaluate the therapeutic effect of the crude preparation of Butea superba tubers on ED..

Results: There was a significant upgrading in 4 of the 5 descriptive evaluations of the IIEF-5 questionnaire. Estimation of the sexual record indicated that;
82.4 % of the patients exhibited noticeable improvement.
Haematology and blood chemistry analysis revealed no apparent change.

Conclusion: The plant preparation appears to improve the erectile function in ED patients without apparent toxicity. [11]

Hair-loss treatment: One small study shows a positive effect on male hair loss in combination with Saw palmetto. Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR).

The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit. [12]

Prostate Health: In Europe, beta-sitosterol plays a major role in treatment of herbal therapy of benign prostatic hypertrophy (BPH) and prostatic carcinoma. The beta-sitosterol group showed a 7.4-point decrease in the International Prostate Symptom Score, compared to a decrease of only 2.1 points in the placebo group . . . a significant 3.5-fold improvement in the men taking beta-sitosterol.

Most remarkably, residual urine in the bladder decreased to 30.4 ml from 65.8 ml in the men using beta-sitosterol, a reduction of almost 54%! In the placebo group, residual bladder urine declined from 64.8 ml to 54.3 ml, a reduction of only around 16%.3 In a follow-up study that evaluated durability of response to beta-sitosterol, the beneficial effects for beta-sitosterol were found to be maintained during an additional 18 months of observation. [13] Prostate health implications of the Asian super fruit cartenoid, FAK KHAAO (Gac fruit)

Cardiovascular health: Epidemiological studies show that genistein intake is inversely associated with the risk of cardiovascular diseases. Genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis. Recent studies found that genistein exerts a novel non-genomic action by targeting on important signaling molecules in vascular endothelial cells (ECs). Genistein rapidly activates endothelial nitric oxide synthase and production of nitric oxide in ECs. [14]

Osteoarthritis anti-inflammatory: Although most studies have focused on the cholesterol-lowering activity of stigmasterol, other bioactivities have been ascribed to this plant sterol compound, one of which is a potential anti-inflammatory effect. This study shows that stigmasterol inhibits several pro-inflammatory and matrix degradation mediators typically involved in OA-induced cartilage degradation, at least in part through the inhibition of the NF-kappaB pathway. [15]

Instructions for Kwao Krua Dang

The daily dose of Kwao Krua Dang is 10mg/kg. A man weighing 80 kg/176 lbs would need 800 mg/day brewed in a tea or 4 #1 gel capsules. For hair-loss treatment, we recommend combined use with saw palmetto.

Toxicity Study

In toxicity experiments with rats, the application of high doses of dried plant material (equivalent to the consumption of 12 to 16 gram daily by an adult man)had a negative impact on several blood parameters and decreased testosterone but not LH levels. At 200 mg/kg BW/day treatment, rats showed significant decreased and increased blood levels of neutrophil and eosinophil, respectively, and a decrease in serum creatinine levels.

The Herb

The Research

Erectile Dysfunction
“ The tuberous roots of Thai B. superba were found to contain flavonoid and flavonoid glycoside with cAMP phosphodiesterase inhibitor activity as well as sterol compounds, including b-sitosterol, campesterol and stigmasterol. B. superba might exhibit a similar effect [to Cnidium monnieri] as it contains a high cAMP phosphodiesterase inhibitor activity, which was directly related to corpus cavernosal vasodilation.
The authors believe that B. superba may act primarily by increasing the relaxation capacity of the corpus cavernosum smooth muscles via cAMP phosphodiesterase inhibition and may also affect the brain, triggering the improvement of the emotional sexual response. It is interesting to note that patients with additional health problems, such as diabetes mellitus, hyper-tension, heart disease and hyperthyroidism, responded satisfactorily to B. superba. ”
An alternative herbal treatment for erectile dysfunction.

Hair-loss treatment
“Biochemically, one contributing factor of this disorder [Androgenetic alopecia (AGA)] is the conversion of testosterone (T) to dihydrotesto­sterone (DHT) via the enzyme 5-alpha reductase (5AR). The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol [contained in Butea Superba], in the treatment of AGA. This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials.”
Effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.

Osteoarthritis anti-inflammatory
“ After 18 h of IL-1beta treatment, MMP-3, MMP-13, ADAMTS-4, but not ADAMTS-5 RNA expression were elevated, as well as MMP-3 and PGE(2) protein levels in mouse and human chondrocytes. Type II collagen and aggrecan mRNA levels were significatively reduced. Pre-incubation of stigmasterol to IL-1beta-treated cells significantly decreased these effects described above. Finally, stigmasterol was capable of counteracting the IL­1beta-induced NF-kappaB pathway.”
Stigmasterol: a phytosterol with potential anti-osteoarthritic properties